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KMID : 0387720170280020163
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Korean Journal of Blood Transfusion
2017 Volume.28 No. 2 p.163 ~ p.169
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Delayed Hemolytic Transfusion Reaction with Alloimmunization of Rh Phenotype: A Two-Case Study
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Yoo Dong-Won
Lee Hyun-Ji
Lee Sun-Min
Kim In-Suk
Song Du-Yeal
Chang Chul-Hun
Shin Kyung-Hwa
Kim Hyung-Hoi
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Abstract
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Delayed hemolytic transfusion reaction is difficult to prevent using an unexpected antibody test performed prior to transfusion, and unlike acute hemolytic transfusion reaction, it occurs a few days after blood transfusion. Hence, determining the reason for delayed hemolytic transfusion reaction may be a tim-consuming task for clinicians Here, we report our experience of two cases of delayed hemolytic transfusion reaction as a result of the unexpected antibody production to Rh blood group antigens after transfusion. The first patient with a history of transfusion during admission was identified as having anti-E and anti-C antibodies according to the antibody identification test at the time of re-admission. The second patient who had chronic blood transfusion due to cancer treatment was found to have anti-C antibody. Both patients received transfusion of Rh antigen-compatible RBC units only after unexpected antibody development. However, like both cases, patients receiving continuous blood transfusion should be considered for a routine Rh phenotype test.
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KEYWORD
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Alloimmunization, Delayed hemolytic transfusion reactions, Rh subgroup, Unexpected antibody
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